Q03518 | TAP1_HUMAN

The ABCB2-ABCB3 (TAP1-TAP2; transporters associated with antigen processing) heterodimer translocates peptide antigens from cytosol to ER for MHCI.

UniProt Entry

UniProt:
Q03518
Start - end:
1 - 808
Sequence length:
808
Sequence MD5 checksum:

Structures

Category, format, type:
AB-INITIO, MMCIF, ATOMIC
Created:
2021-11-21
Method, confidence:
THEORETICAL MODEL, ipTM+pTM = 83.23
AlphaFold2-Multimer v2.1.0 release with memory error bug fixes ([github/hegelab/betafold](https://github.com/hegelab/betafold-2.1.0)) were used for the prediction. The `--full_dbs` option, which runs with all genetic databases used at CASP14, was set. Database versions were the same as in the initial AF2 release, except UniClust30, for which we used the 2021_06 release, since `hhblits` produced error for some sequences when using `uniclust30_2018_08`. The `--max_template_date` argument was set into the future to utilize all available experimental structures as potential templates. The structure top ranked based on ipTM+pTM score were selected and presented as a PDB formatted file (its name ends with full.pdb). Low complexity regions were visually inspected and removed if concluded non-sense (e.g. traversing membrane region) and presented as the main cif and pdb files.
UniProt start - end, coverage:
65 - 808, 92%
Oligomeric state (chains):
HETERODIMER ()
Literature:
To be published.
Cif file:
hege-abc-0014.cif
PDB file:
hege-abc-0014.pdb
Full predicted pdb file:
hege-abc-0014.full.pdb
All structure files:
hege-abc-0014.zip